Containing the PlaqueOff powder, it works systemically and it begins by working its way into the saliva which coats all of the teeth. This slowly begins to alter the deposits on teeth making them change to a softer, gloopier texture. The bones also have an abrasive action, helping to scrape away the softened deposits. Designed for all dogs, and can be broken in half for smaller dogs. Suitable for puppies once all their adult teeth are fully through.